Recurrent ICU Admissions for Airway Protection in a Young Female with Hereditary Angioedema: A Case Report

Abstract

Hereditary angioedema (HAE) is a rare condition that may involve life-threatening upper airway swelling. A 19-year-old female with known C1 esterase inhibitor deficiency presented multiple times with lip and tongue swelling without stridor. She was electively intubated for airway protection during each episode and treated with Berinert®, resulting in symptom resolution. Hormonal and prophylactic therapy was initiated after repeated ICU admissions. This case highlights the need for high suspicion and early airway intervention in HAE, even in the absence of overt respiratory distress. Prompt airway management and tailored long-term treatment are essential in managing recurrent angioedema.