HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State

Authors

  • Sriram Mudraje Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.
  • Nancy Garg Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.
  • Jaideep Khare Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.
  • Sushil Jindal Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.

DOI:

https://doi.org/10.18502/crcp.v9i6.18947

Keywords:

HAIR-AN syndrome; Hyperinsulinemia; Insulin resistance; Hyperandrogenemia

Abstract

Insulin resistance is categorized as type A or type B, depending on the etiology. HAIRAN syndrome is a subtype of type A insulin resistance. It is characterized by high insulin resistance, hyperandrogenemia, and hyperinsulinemia. Here, we present a 12-year-old girl who was lean during her first decade of life and came with complaints of gradual-onset weight gain, darkening of her neck and limbs, and roughening of her skin. Menarche had not been attained. She had Grade 4 acanthosis nigricans, thick coarse skin, and hirsutism. Investigations revealed raised blood glucose, elevated testosterone, elevated fasting insulin, and raised HOMA-IR. With biochemical evidence of hyperandrogenemia, insulin resistance, and the presence of acanthosis nigricans, the diagnosis of HAIR-AN syndrome was made.

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Published

2025-06-27

Issue

Volume (9) issue (6)

Section

Articles