Inflammatory Parameters in UTIs Infection Caused by E. coli in Diabetic Patients

Abstract

Background: Urinary tract infections (UTIs) are a public health concern, mainly for diabeticinfections, who are more susceptible due to weakened immunity and high blood sugar. Understandingthe role of immune parameters can help improved diagnose and attendant more effective treatmentfor diabetic mellitus patients with UTIs. This study aims to estimate the serum levels of AGEs, SAA,PCT, CD23 and CD25 in UTIs caused by E. coli in Diabetic Patients.Methods: This study had been included 300 samples (blood for Inflammatory parameters and urinefor bacterial diagnosis) obtained from Diabetic patients found in Al-Betool Teaching Hospital. AndBaquba Teaching Hospital between June 2023 and August 2024. Urine and blood samples werecollected from 300 individuals with diabetes mellitus with both type who were suspected of havingUTIs. Serum was isolated from the blood, blood glucose and HBA1c test was completed to check thepresence of the diabetic illnesses. The serum samples were then stored for used in measuringimmunological parameters that includes AGEs, SSA, PCT, CD23 and CD25 that done later byELISA. Urine samples were culture on the blood agar and MacConkey agar, and then Bacteriadiagnoses was done by using an automatic VITEK 2 system.Results: The current study showed that 220 samples urinary tract infections, 180 of which werebacterial. Of the 180 samples, 116 have E. coli bacterial isolates and 46 have other bacterial species.The study also shown an increase in the concentration of AGEs, SAA, PCT, CD23 and CD25 in theserum of Diabetic Mellitus patients have UTIs compared with the healthy.Conclusion: These inflammatory markers not only serve as diagnostic tools but also help inunderstanding the complex immune dysfunction present in diabetic patients with UTIs caused by E.coli.