Biofilm Formation by Quorum Sensing and Manners to Deal It

Shahriar Bakhti; Ahdiyeh Saghabashi; Shahrzad Aliniay Sharafshadehi; Samad Rastmanesh; Narjess Bostanghadiri; Ali  Jalilpiran; Javad Fathi; Alireza Gholipour Shahraki; Fatemeh Sameni

doi:10.18502/jmb.v12i2.15626

Shahriar Bakhti Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Ahdiyeh Saghabashi Department of Microbiology, Faculty of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Shahrzad Aliniay Sharafshadehi Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Samad Rastmanesh Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Narjess Bostanghadiri Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ali Jalilpiran Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Javad Fathi Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza Gholipour Shahraki Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Fatemeh Sameni Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.

DOI: https://doi.org/10.18502/jmb.v12i2.15626

Keywords: Biofilm, Burkholderia cepacia, Listeria monocytogenes, Pseudomonas aeruginosa, Quorum Sensing, Staphylococcus aureus.

Abstract

Background: Quorum sensing (QS) is one of the main regulatory systems which have various effects on populations of microorganisms. This process has been found in a diverse array of microorganisms (various bacterial taxa, microalgae and fungi). QS is required for different activities of microorganisms such as, virulence factor secretion, motility, competence, biofilm and sporulation. There are different molecules as signals in disparate microorganisms. Biofilm formation is one of the significant functions of QS. Biofilms are groups of microorganisms that are tied to a surface (biotic or abiotic). One of the remarkable effects of biofilm formation seems to be the persistence against hostile environmental condistions. Biofilm formation have been widely reported as a pathogenesis strategy in microorganisms. Here we describe QS and biofilm formation in some important microorganisms and describe some of the suggested strategies for eradication of microbial biofilms.

Conclusion: Inhibition of biofilms formation can have detectable effects on the treatment of infectous diseases. In this line, multiple approaches have been suggested to inhibit the biofilm formation by microorganisms.