PIN1 as a Predictive Biomarker for H. pylori Infection–Associated Gastric Cancer

Fateme Karimi  Dermani; Hamid Sadeghi; Fatemeh  Samiee-Rad; Saeideh Gholamzadeh Khoei

doi:10.18502/jmb.v11i3-4.14368

Fateme Karimi Dermani Hellen Diller Family Cancer research, University of California San Francisco, United States of America.
Hamid Sadeghi Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Fatemeh Samiee-Rad Clinical Research Development Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Saeideh Gholamzadeh Khoei Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

DOI: https://doi.org/10.18502/jmb.v11i3-4.14368

Keywords: Biomarker, Gastric Cancer, H. pylori, PIN1.

Abstract

Cancer is now one of the major causes of death across the globe. Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), has recently emerged as a critical factor in various cancers. Numerous studies have shown that PIN1 is highly expressed in several cancer types and is significantly associated with the prognosis of patients with a certain type of tumor such as gastric cancer. Meanwhile, some studies have indicated that infection with Helicobacter pylori significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. In this article, we propose that PIN1 can play a vital role in the prognosis of Helicobacter pylori infection-associated with peptic ulcer disease and can be effective in order to provide the best cure and the choice for treatment.