The Covid-19 Infection Effect on Assisted Reproductive Method Outcomes

Niloofar Poursaadat; Pershang Nazemi; Saeideh Shams Zamenjani; Naghmeh Pourmand; Razieh Mohammadkhani; Firoozeh  Akbari Asbagh

doi:10.18502/jfrh.v18i2.15930

Niloofar Poursaadat Department of Infertility, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Pershang Nazemi Department of Infectious Diseases, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Saeideh Shams Zamenjani Department of Infertility, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Naghmeh Pourmand Department of Infertility, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Razieh Mohammadkhani Department of Infertility, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Firoozeh Akbari Asbagh Department of Infertility, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jfrh.v18i2.15930

Keywords: In Vitro Fertilization; COVID-19; Embryo Transfer; Oocyte Retrieval

Abstract

Objective: COVID-19 can have potential pathogenic effects on the oocyte and embryos, but there is limited data about its impact. This study aimed to investigate the COVID-19 impact on the outcome of Assisted Reproduction Techniques (ART) methods.

Materials and methods: This case-control study was conducted on 190 infertile women who underwent oocyte retrieval at Yas Hospital in vitro fertilization (IVF) department affiliated to Tehran University of Medical Sciences, from October 2021 to October 2022. The case group was defined as women whose PCR test was positive on puncture day and the control group was women with COVID-19 negative tests on puncture day. The study outcome measurements included the number of oocytes retrieved and the number and quality of embryos. Finally, the data were analyzed by SPSS 24.

Results: The mean age of the participants was 32.89 ± 5.58 years with an age range of 18-49 years. No significant difference was observed between the two groups regarding baseline variables. The mean number of oocytes was significantly (p =0.001) lower in the case (6.68±4.25) group versus the control (9.07±4.10) group. While there was no statistically significant difference regarding the mean number of embryos in the study groups, No grade A embryos were observed in more than half (57.5%) of the women in the case group. Furthermore, the frequency of grade C embryos on average was 1.08±1.11 in the case group and 0.57±0.75 in the control group, with a statistically significant difference (p =0.010).

Conclusion: The findings of this research highlighted that women infected with COVID-19 on the puncture day have a lower number of oocytes and also good-quality embryos.