Could Maternal Vitamin D Concentration Affect Cervical Length in Mid-Pregnancy? A Report from an Iranian Tertiary Center

  • Azadeh Shabani Obstetrics and Gynecology Department, Faculty of Medicine, Shahid Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Amene Abiri Obstetrics and Gynecology Department, Faculty of Medicine, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Seyedeh Noushin Ghalandarpoor-Attar Obstetrics and Gynecology Department, Faculty of Medicine, Baqyiatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Alireza Hadizadeh Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Seyedeh Mojgan Ghalandarpoor-Attar Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Vitamin D; Cervical Length; Body Mass Index; Deficiency; Pregnancy; Maternal

Abstract

Objective: This descriptive-analytic cross-sectional study aimed to figure out whether maternal serum vitamin D concentration correlates with cervical length measurement in mid-gestation or not.

Materials and methods: During Jun-Jan 2021, 213 pregnant women at 18-22 weeks of gestation were investigated. First, demographic features were obtained then, maternal serum vitamin D concentration was measured by enzyme-linked immunoassay and cervical length was measured via transvaginal sonography according to fetal maternal foundation guideline and appropriate statistical test was used to analyze the correlation between maternal vitamin D level and cervical length in mid-pregnancy.

Results: It was shown that 29.6% and 25.4% of participants had vitamin D deficiency and insufficiency, respectively. Spearman’s test found no significant correlation between maternal vitamin D level and cervical length in mid-pregnancy. Moreover, cervical length and maternal vitamin D level had no association with maternal BMI.

Conclusion: Although maternal vitamin D level and its sufficiency status was not associated with cervical length in mid- pregnancy, as a trend toward decreased maternal serum vitamin D level by advancing gestational age was observed. It may be concluded that it is prolonged vitamin D deficiency during gestation that may lead to cervical length shortening and subsequent preterm delivery later in gestation.

 

Published
2022-12-13
Section
Articles