Could Maternal Vitamin D Concentration Affect Cervical Length in Mid-Pregnancy? A Report  from an Iranian Tertiary Center

Azadeh Shabani; Amene Abiri; Seyedeh Noushin  Ghalandarpoor-Attar; Alireza  Hadizadeh; Seyedeh Mojgan  Ghalandarpoor-Attar

doi:10.18502/jfrh.v16i4.11360

Azadeh Shabani Obstetrics and Gynecology Department, Faculty of Medicine, Shahid Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amene Abiri Obstetrics and Gynecology Department, Faculty of Medicine, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
Seyedeh Noushin Ghalandarpoor-Attar Obstetrics and Gynecology Department, Faculty of Medicine, Baqyiatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran
Alireza Hadizadeh Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Seyedeh Mojgan Ghalandarpoor-Attar Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jfrh.v16i4.11360

Keywords: Vitamin D; Cervical Length; Body Mass Index; Deficiency; Pregnancy; Maternal

Abstract

Objective: This descriptive-analytic cross-sectional study aimed to figure out whether maternal serum vitamin D concentration correlates with cervical length measurement in mid-gestation or not.

Materials and methods: During Jun-Jan 2021, 213 pregnant women at 18-22 weeks of gestation were investigated. First, demographic features were obtained then, maternal serum vitamin D concentration was measured by enzyme-linked immunoassay and cervical length was measured via transvaginal sonography according to fetal maternal foundation guideline and appropriate statistical test was used to analyze the correlation between maternal vitamin D level and cervical length in mid-pregnancy.

Results: It was shown that 29.6% and 25.4% of participants had vitamin D deficiency and insufficiency, respectively. Spearman’s test found no significant correlation between maternal vitamin D level and cervical length in mid-pregnancy. Moreover, cervical length and maternal vitamin D level had no association with maternal BMI.

Conclusion: Although maternal vitamin D level and its sufficiency status was not associated with cervical length in mid- pregnancy, as a trend toward decreased maternal serum vitamin D level by advancing gestational age was observed. It may be concluded that it is prolonged vitamin D deficiency during gestation that may lead to cervical length shortening and subsequent preterm delivery later in gestation.