Comparative Analytical study of Dinoprostone Gel  and Hyaluronidase Injection for Induction of labour  in Term Primigravida in Tertiary Rural Medical Centre  of Western Uttar Pradesh

Neelam Swaroop; Shaheen Bano; Soniya Vishwakarma; Nupur Mittal; Vaibhav Kanti; Vandana Gupta; Pragya Shree

doi:10.18502/jfrh.v16i3.10577

Neelam Swaroop T.S. Mishra Medical College Lucknow, Uttar Pradesh, India
Shaheen Bano Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Soniya Vishwakarma Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Nupur Mittal Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Vaibhav Kanti Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Vandana Gupta Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India
Pragya Shree Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

DOI: https://doi.org/10.18502/jfrh.v16i3.10577

Keywords: Induction of labour; Dinoprostone Gel; Intracervical Hyaluronidase Injection; Bishop Score

Abstract

Objective: To compare the efficacy of intracervical dinoprostone gel and hyaluronidase injection for induction of labour in term primigravida.

Materials and methods: This is a hospital based analytical prospective interventional study conducted in a rural tertiary care centre over a period of 18 months. A total of 70 patients who required induction of labour for one or another reason with Bishop score of less than 6 were included in the study. All the cases were randomly divided into two groups, Group A received dinoprostone gel and Group B received hyaluronidase injection. Chi square test & unpaired T test were applied for statistical analysis.

Results: Time interval from induction to active phase of labour was comparatively shorter in group A than in group B (10.74 ± 6.17 vs 15.94 ± 7.1) and the difference was significant (p= 0.001). Time interval from induction to delivery time was comparatively shorter in group A than group B (14.84 ± 8.86 vs 21.33 ± 7.86) and difference was significant (P= 0.009). Maternal complications were more common in group A as compared to group B.

Conclusion: This study showed that labour could be accelerated significantly by intracervical injection of hyaluronidase. Hyaluronidase injection has less maternal and fetal side-effects as compared to dinoprostone gel and can be a good choice for induction of labour.