Estimation of Polychlorinated Biphenyls Intake through  Fish Oil-Derived Dietary Supplements and Prescription Drugs  in the Japanese Population

Y.   Matsuo; K.  Nakai; I.  Sakuma; K.   Akutsu; N.  Tatsuta; M.   Ishiyama; T.   Higuchi; N.  Ryuda; D.  Ueno

doi:10.18502/jfqhc.6.4.1992

Y. Matsuo
K. Nakai
I. Sakuma
K. Akutsu
N. Tatsuta
M. Ishiyama
T. Higuchi
N. Ryuda
D. Ueno

DOI: https://doi.org/10.18502/jfqhc.6.4.1992

Keywords: Polychlorinated Biphenyls Fish Oils Dietary Supplements Prescription Drugs Risk Assessment Japan

Abstract

Background: Oily fish and their extracted oils may be a source of polychlorinated biphenyls (PCBs) which can induce toxic effects on the consumers. The main aim of this survey was estimation of PCBs intake through fish oil-derived dietary supplements and prescription drugs in the Japanese population. Methods: PCBs levels were determined in 20 fish oil-derived dietary supplements and 6 oil-derived prescription drugs from the Japanese market using Gas Chromatography-Mass Spectrometry. Then, the daily exposure to PCBs was estimated. Data were statistically analyzed using JMP software suite. Results: Totally, 17 of the 26 fish oil-derived products were contaminated with PCBs. The median PCB concentrations in the total set of fish oil-derived products was 2.2 ng/g oil wt. with a range of <MDL-720 ng/g oil wt. The average total daily intake of PCBs was estimated to be ranged from 770 to 2800 ng/day in the Japanese population. Conclusion: PCBs intakes through fish oil-derived dietary supplements and prescription drugs in the Japanese adults were much lower than tolerable daily intake