Assessing VEGF mRNA and miR-494 expression in peripheral blood collected from patients suffering from oral squamous cell carcinoma

Maryam   Khani; Abdolreza   Mohamadnia; Farzaneh  Hosseini; Parisa   Bayat; Naghmeh   Bahrami

doi:10.18502/jcr.v6i1.1628

Maryam Khani
Abdolreza Mohamadnia
Farzaneh Hosseini
Parisa Bayat
Naghmeh Bahrami

DOI: https://doi.org/10.18502/jcr.v6i1.1628

Keywords: OSCC, early diagnosis, VEGF mRNA, miR-494

Abstract

Introduction: oral squamous cell carcinoma accounts for 2% of all cancers and also is one of the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR-494 expression.

Method and material: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR-494 expression in peripheral blood with real-time PCR technique.

Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR-494 was positive in 20 out of 30 patients.

Results: overall based on this article's findings, results could count as a diagnostic screening test for OSCC detection in early steps of cancer.