Solitary Intraosseous Neurofibroma of Mandible: Report of a Case

Amir Jalal  Abbasi; Pouyan Aminishakib; Mani  Arashrad

doi:10.18502/jcr.v10i4.15314

Amir Jalal Abbasi Department of Oral and Maxillofacial Surgery, Sina Hospital, Tehran University Of Medical Sciences, Tehran, Iran.
Pouyan Aminishakib Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Mani Arashrad Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jcr.v10i4.15314

Keywords: Intraosseous neurofibroma, Mandible

Abstract

Neurofibroma is a benign tumor derived from the peripheral nerve. Most of these can be multifocal as a component of neurofibromatosis or present as a solitary tumor. Although the solitary neurofibroma is not an uncommon lesion, its intraosseous occurrence is rare, and less than 50 cases have been reported.

We report a rare case of central neurofibroma, arising in the mandibular bone of 57-year-old edentulous female patient on the left side. Hemi mandibulectomy was performed and reconstructed with a reconstruction plate without any bone graft. Microscopic evaluation showed neoplastic tissue with haphazardly arranged and interlacing fascicular patterns composed of point-ended spindle-shaped tumoral cells. Immunohistochemical examination of the tumor showed positive staining for S-100 protein antibodies.