Reconstruction of alveolar defects with regenerative properties of adipose-derived stem cells

Mohammad  Bayat; Sarvenaz  Karimi Aval; Mohammad Hosein Amirzade; Abdolreza Mohamadnia; Naghmeh  Bahrami

doi:10.18502/jcr.v10i2.14050

Mohammad Bayat Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Sarvenaz Karimi Aval Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hosein Amirzade Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Abdolreza Mohamadnia Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Naghmeh Bahrami Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.

DOI: https://doi.org/10.18502/jcr.v10i2.14050

Keywords: Alveolar bone reconstruction; Mesenchymal stem cell; Adipose-derived stem cells; Natural bovine bone mineral.

Abstract

Introduction: Loss of tissue and dysfunction of body organs due to injuries and diseases have caused serious health problems despite the vast advances in Medicien. Bone repair through tissue engineering is one of the most important areas of attention for specialists in a wide range of de- partments, including orthopedics and maxillofacial surgeries.

Materials and Methods: This case-series describes efficient clinical applications of adi- pose-derived stem cells (AdSCs) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after hemi-mandibulectomy.

Results: As the result, this approach represented a considerable amount of three-dimensional bone formation in presented cases. Regenerating this amount of resected bone tissue rehabilitates the patients and gives clinicians a sufficient amount of bone and opportunity to insert dental implants to retrieve patients’ function and aesthetic.

Conclusion: The application of AdSCs can be considered as an efficient treatment for bone regeneration in large alveolar bone defects.