The Stimulatory Effects of Medicinal Plants on β2-adrenoceptors  of Tracheal Smooth Muscle

Farzaneh Shakeri; Vahideh Ghorani; Saeideh Saadat; Zahra Gholamnezhad; Mohammad Hossein Boskabady

doi:10.18502/ijaai.v18i1.627

Farzaneh Shakeri
Vahideh Ghorani
Saeideh Saadat
Zahra Gholamnezhad
Mohammad Hossein Boskabady

DOI: https://doi.org/10.18502/ijaai.v18i1.627

Keywords: β2-adrenoceptors; Medicinal plant; Possible mechanism; Stimulatory effect; Tracheal smooth muscle

Abstract

Medicinal plants have been identified and used as primary sources in prevention and treatment of pulmonary diseases (mainly obstructive pulmonary diseases) from ancient times due to various pharmacological activities. In this review, the stimulatory effects of extracts, some fractions and constituents of medicinal plants on β₂-adrenoceptors which could be used as possible therapeutic agents in the future were reviewed.

Various databases including; Medline, PubMed, ScienceDirect, Scopus, and Google Scholar were searched using stimulatory effect, β₂-adrenoceptors, possible mechanism, tracheal smooth muscle (TSM), medicinal plants and their constituents as keywords from 1985 to 2017.

All studied plants including; Nigella sativa, Rosa damascena, Thymus vulgaris, Carum copticom, Carum carvi, Zataria multiflora, Crocus sativus, Cuminum cyminum, Liomnia acidissima, Portulaca oleraceae, Satureja hortensis, Ephedra sinica and Achillea millefolium showed relaxant effect on tracheal smooth muscle with a stimulatory effect on β₂-adrenoceptors mechanism.

The studied plants and their constituents could be of therapeutic value in clinical practice as a bronchodilatory drug by β₂-adrenoceptors stimulatory mechanism for treatment of obstructive pulmonary diseases.