Toll-like Receptor 3 Deficiency in a Child with Recurrent Infections  and Diabetes Mellitus

Nasrin  Moazzen; Hamid   Ahanchian; Samaneh   Norooziasl; Hamid Reza  Kianifar

doi:10.18502/igj.v3i4.7467

Nasrin Moazzen Clinical Research Development Unit of Akbar hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid Ahanchian Clinical Research Development Unit of Akbar hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Samaneh Norooziasl Department of Pediatric Endocrinology, Mashhad University of medical sciences, Mashhad, Iran
Hamid Reza Kianifar Clinical Research Development Unit of Akbar hospital, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.18502/igj.v3i4.7467

Keywords: Toll-Like Receptor 3 Deficiency; Diabetes Mellitus; Recurrent Infections; Skin Lesions

Abstract

There are more than 400 different primary immune deficiencies worldwide. Amongst them, patients with humoral immunodeficiency are more common. Most of the innate immune defects, affect the phagocytic system. There are a few cases of toll-like receptor deficiency with innate immune defects, like TLR3 mutations, which usually present with Herpes simplex encephalitis. Herein, we report a two-year old boy with TLR3 deficiency, who was presented with recurrent infections and type one diabetes mellitus.