Evaluation of Serum Level of Interleukin 1 in Patients Suffering from  Acute Coronary Syndrome, Admitted to the CCU Ward of AmirAlmomenin Hospital of Zahedan

Hossein Ali  Khazaei; Ahmad  Bolouri; Hony  Harati; Mehdi   Mohammadi; Sayed Mohammad   Nasiraldin  Tabatabei; Amin   Khazaei; Masoud  Pishjuo; Zahra  Ayoubi Yazdi; Bahman  Khazaei

doi:10.18502/igj.v3i4.7461

Hossein Ali Khazaei Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.
Ahmad Bolouri Department of Cardiovascular diseases of Zahedan University of Medical Sciences, Zahedan-Iran.
Hony Harati Department of Cardiovascular diseases of Zahedan University of Medical Sciences, Zahedan-Iran.
Mehdi Mohammadi Department of Biostatistics of Zahedan University of Medical Sciences, Zahedan-Iran.
Sayed Mohammad Nasiraldin Tabatabei Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.
Amin Khazaei Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.
Masoud Pishjuo Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.
Zahra Ayoubi Yazdi Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.
Bahman Khazaei Clinical Immunology Research Center and Dept. of Immunology and hematology, Zahedan University of Medical Sciences, Zahedan-Iran.

DOI: https://doi.org/10.18502/igj.v3i4.7461

Keywords: Atherosclerosis; IL-1; Unstable Angina; Myocardial Infarction with Q Wave and Non Q Wave

Abstract

Background: Atherosclerosis is a disease in which the particles of fat builds up in the blood vessel’s walls. This build up leads to blood flow blockage or can cause the arteries to narrow, but until the stenosis of the vessel is not more than 70 percent, there won’t be any obvious symptoms. Symptoms are dependent on the location of the stenosis that can bring about diseases such as, Unstable Angina (UA), Myocardial Infarction with Q Wave (MIQW) and Non Q Wave (NMIQW). The most common causes of death in most developed countries is Coronary Artery Disease (CAD), and since the inflammatory factors are one of the causes of these diseases, we decided to evaluate the level of the Interleukin-1 (IL-1) in patients with acute coronary syndrome.

Methods: 90 patients, suffering from the acute coronary syndrome were selected, which were previously diagnosed and referred to a cardiologist in the Imam Ali Ebneh hospital’s cardiac ward, in 2011. Five ml of periphery blood was obtained from each patient, after 24 hours of hospitalization. Using the ELISA method, the level of interleukin-1 was measured in the three groups of patients, each with symptoms of UA, MIQW and MINQW.

Results: Our findings, showed the highest level of interleukin-1 in the MIQW patients, with the average of 46.55 pg/ml and, the lowest level in the MINQW patients, with the average of 28.17 pg/ml. Moreover, the average level of IL-1 in the patient’s serum with UA, is determined equal to 31.28 pg/ml. Although, there was no significant correlations between the type of MI development and UA, there was a significant correlation between the level of IL-1 and the type of MI development.

Conclusion: Despite the fact, that the level of IL-1 was higher than normal in all the group types, and no significant correlation between the type of MI development and UA was found, there was statistically a significant correlation between the types of MI development and the level of IL-1.