Cytokine Patterns in Iranian Patients with Asthma

Soheila  Alyasin; Zahra  Kanannejad; Hossein  Esmaeilzadeh; Hesamedin Nabavizadeh; Reza  Amin

doi:10.18502/igj.v3i4.7455

Soheila Alyasin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Kanannejad Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Esmaeilzadeh Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Hesamedin Nabavizadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Reza Amin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/igj.v3i4.7455

Keywords: Cytokine; Level; Asthma; Biomarker; Iran

Abstract

Asthma is one of the most common respiratory diseases caused by chronic airway inflammation. A complex network of cytokines could affect asthma development. IL-4, IL-13, IL-17, and IL-33 have been identified as cytokines associated with asthma severity and these cytokines can be considered as candidate biomarkers for predicting the asthma severity while the IL-10 is lower in asthmatics compared with healthy subjects. There are many controversies about the IL-22, IL-25, and TGF-β levels between the Iranian publications. No significant differences have been observed between the healthy subjects and the asthmatic cases regarding the IL-6 and IL-8.