Vaccination in Patients with Primary Immunodeficiency Disorders

  • Abbas Khalili Department of pediatrics, Shahid Sadoughi University of medical sciences, Yazd, Iran.
Keywords: Vaccination; Primary Immunodeficiency; Live-attenuated Vaccine; Inactivated Vaccine


Primary Immunodeficiency Disorders (PID), are heterogeneous groups of an abnormality in innate and adoptive immune systems. Patients with these disorders, are susceptible to lifethreatening infections. Infection control, is an important strategy for improving the quality of life and prognosis. Prophylaxis, intravenous immunoglobulin and antibiotic therapy for a long period of time, is an appropriate option for many patients with PID. But vaccination in immunocompromised patients may play a significant role and various outcomes. Depending on the type of PID, there are different results after the administration of vaccines in patients. In some cases, immune response is perfect and there is a well protection against the syndromes. On the other hand, in some other patients, immune response is impaired, and the vaccination is ineffective or even could lead to severe overwhelming side effects. To date, there are no wellestablished guidelines about the vaccination of immunocompromised people. In this review, we are going to describe the latest recommendations for the immunization of patients with PID, based on the published literatures.