A National Consensus on Hematopoietic Stem Cell Transplantation for Patients with Inborn Errors of Immunity

Reza  Yazdani; Samanah  Abdolahzadeh; Marjan  Aghajani; Mina  Ahmadi; Mostafa  Alavi-Moghaddam; Saba  Arshi; Maryam Asarehzadegan  Dezfouli; Marzieh  Asgharyan; Parisa  Ashournia; Aida  Askarisarvestani; Raheleh  Assari; Hadi  Badiee; Sima  Bahrami; Maryam  Behfar; Nasrin  Behniafard; Zahra  Chavoshzadeh; Mahsa Choroom  Kheirabadi; Zahra  Daneshmandi; Mohammad Hassan  Bemanian; Taher  Cheraghi; Kian  Darabi; Sepideh  Darougar; Sarehsadat  Ebrahimi; Golnaz  Eslamian; Maryam  Esmaeilbeig; Morteza  Fallahpour; Nader  Faraji; Shahin  Farzadmanesh; Kimiya HajiAbbasi  Someesaraie; Arash  Kalantari; Mahdieh  Karimizadeh; Elham  Kaviani; Mehrnaz  Mesdaghi; Majid  Marjani; Mohammadreza  Modaresi; Iraj  Mohammadzadeh; Mahshid  Movahedi; Masoud  Movahedi; Mostafa  Moosavian; Mohammamd  Nabavi; Leyla  Norouzi-Barough; Anahita  Razaghian; Mansoureh  Shariat; Sahar  Seraj; Soodeh  Seyedi; Seyedehshabnam  Seyedsalehi; Alireza  Shafiei; Zahra Shahraki  Ghadimi; Behzad  Shakerian; Samin  Sharafian; Sima  Shokri; Marzieh  Tavakol; Ahmad Vosughi  Motlagh; Nima  Rezaei

doi:10.18502/igj.v9i1.21880

Reza Yazdani Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Samanah Abdolahzadeh Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Marjan Aghajani Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mina Ahmadi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Mostafa Alavi-Moghaddam Department of Emergency Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saba Arshi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Maryam Asarehzadegan Dezfouli Allergy and Clinical Immunology Clinic, AbuRehan Polyclinic, Social Security Organization. Tehran, Iran
Marzieh Asgharyan Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Parisa Ashournia Department of Allergy and Clinical Immunology, Bahrami Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Aida Askarisarvestani Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Raheleh Assari Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran, Iran
Hadi Badiee Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sima Bahrami Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Maryam Behfar Pediatric Cell and Gene Therapy Research Centre, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Nasrin Behniafard Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Zahra Chavoshzadeh Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahsa Choroom Kheirabadi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Zahra Daneshmandi Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Hassan Bemanian Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Taher Cheraghi Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran
Kian Darabi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Sepideh Darougar Department of Pediatrics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Sarehsadat Ebrahimi Department of Immunology and Allergy, Kerman University of Medical Sciences, Kerman, Iran
Golnaz Eslamian Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Esmaeilbeig Department of Allergy and Clinical Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
Morteza Fallahpour Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Nader Faraji Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Shahin Farzadmanesh Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Kimiya HajiAbbasi Someesaraie Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Arash Kalantari Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran.
Mahdieh Karimizadeh Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elham Kaviani Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mehrnaz Mesdaghi Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Majid Marjani Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammadreza Modaresi Pediatric Pulmonary Disease and Sleep Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center Hospital, Tehran, Iran.
Iraj Mohammadzadeh Non-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; USERN Office, Babol University of Medical Sciences, Babol, Iran.
Mahshid Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran; Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran.
Masoud Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mostafa Moosavian Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammamd Nabavi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Leyla Norouzi-Barough Immunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Anahita Razaghian Department of Allergy and Clinical Immunology, Hakim Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran; Immunology, Allergy and Asthma Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mansoureh Shariat Department of Immunology and Allergy, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sahar Seraj Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soodeh Seyedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Seyedehshabnam Seyedsalehi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Alireza Shafiei Department of Allergy and Immunology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Zahra Shahraki Ghadimi Department of Pediatrics, Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Behzad Shakerian Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Samin Sharafian Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sima Shokri Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Marzieh Tavakol Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Ahmad Vosughi Motlagh Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Nima Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/igj.v9i1.21880

Keywords: Consensus; Hematopoietic Stem Cell Transplantation; HSCT; Inborn Errors of Immunity; IEI

Abstract

At present, a national consensus on hematopoietic stem cell transplantation (HSCT) for patients with inborn errors of immunity (IEI) is lacking. This consensus is written based on a combination of scientific literature and comments from the expert panel of Iranian immunologists. We formed a panel of clinical immunologists at a meeting titled “Second Meeting on the Diagnosis of IEI by IEI Experts” to receive their comments in this field. All authors reviewed and agreed on the current consensus. This consensus guideline provides recommendations on donor selection, stem cell source, conditioning regimen, mobilization and collection, stem cell infusion, engraftment and chimerism assessment, and post-trans- plant care for patients with IEI. The current recommendations reflect Iranian practice and do not necessarily represent global preferences