Hematological Parameters in Patients with Allergic Rhinosinusitis Combined with Chronic Allergic Otitis Media

Ashur  Qosimzoda; Makhsum  Bustonov; Sayfullo  Rakhmonov; Zohid  Shermatov; Bobur  Bustonov

doi:10.18502/igj.v8i4.20100

Ashur Qosimzoda Department of Surgical Disciplines, Khatlon State Medical University, Tajikistan
Makhsum Bustonov Department of Surgical Disciplines, Khatlon State Medical University, Tajikistan
Sayfullo Rakhmonov Department of Surgical Disciplines, Khatlon State Medical University, Tajikistan
Zohid Shermatov Department of Surgical Disciplines, Khatlon State Medical University, Tajikistan
Bobur Bustonov Department of Surgical Disciplines, Khatlon State Medical University, Tajikistan

DOI: https://doi.org/10.18502/igj.v8i4.20100

Keywords: Allergic Rhinosinusitis; Chronic Otitis Media; Eosinophilia; Hematological Parameters

Abstract

Background: Allergic rhinosinusitis (ARS) and chronic allergic otitis media are common manifestations of upper airway allergic inflammation. Despite advances in understanding the immunopathogenesis of these conditions, hematological markers reflecting systemic immune activation remain underexplored, particu- larly in combined presentations. To evaluate hematological parameters, with emphasis on leukocyte sub- populations and the eosinophil-lymphocytic index, in patients with allergic rhinosinusitis combined with chronic allergic otitis media compared to non-allergic chronic otitis media.

Methods: Archival records of 60 adult patients (33 males, 27 females; mean age 41.2 years) from the Otorhinolaryngology Department of the National Medical Center “Shifobakhsh,” Republic of Tatarstan, were analyzed. Group I (n=30) included ARS with CAOM, and Group II (n=30) included non-allergic COM. Complete blood count (CBC) with leukocyte differential and ELI were assessed and compared de- scriptively. Correlation analysis between leukocyte subpopulations was also performed.

Results: Mean total leukocyte count in allergic patients was near the upper normal range (8.9×10⁹/L). Leukocytosis was observed in 16.7% of allergic versus 40% of non-allergic cases. Peripheral eosinophilia (>5%) was observed in 63.3% of patients with allergies, with a mean eosinophil count of 5.8%. Relative lymphocytosis occurred in 40% of allergic and 16.7% of non-allergic patients, while absolute lymphocyte counts were lower in the allergic group. ELI was increased in 43.3% of patients with allergies. Correlation analysis revealed strong relationships (η>0.90) between neutrophils, eosinophils, and monocytes in both groups, indicating coordinated immune responses.

Conclusion: Peripheral eosinophilia and elevated ELI serve as indirect hematological markers of systemic allergic sensitization in ARS with CAOM. These findings support using simple blood parameters as adjunc- tive indicators of allergic inflammation when specialized allergy testing is unavailable.