National Consensus Guideline on Diagnosis and Management of Chronic Granulomatous Disease

Samaneh Delavari; Reza Yazdani; Hassan Abolhassani; Fereshte Salami; Parisa Ashournia; Aida Askarisarvestani; Sima Bahrami; Maryam Behfar; Mohammad Hassan Bemanian; Taher Cheraghi; Kian Darabi; Sepideh Darougar; Sarehsadat EbrahimiEbrahimi; Shabnam Eskandarzadeh; Golnaz Eslamian; Narges Eslami; Shahrzad Fallah; Morteza Fallahpour; Saba Fekrvand; Ali Haghbin; Zohre Hassanpoor; Tolue Mahdavi; Homa Hatefi Minaei; Majid Marjani; Shahla Mirazizi; Mohammadreza Modaresi; Mahshid Movahedi; Mohammamd Nabavi; Mojtaba Ranjbar; Anahita Razaghian; Mohammad Saberi; Mahnaz  Sadeghi-Shabestari; Mitra Sahragard; Kiarash Saleki; Sahar Seraj; Seyedehshabnam Seyedsalehi; Alireza Shafiei; Roya Sherkat; Reza Shiari; Sima Shokri; Saman Tavakoli; Ahmad Vosughimotlagh; Nima Rezaei

doi:10.18502/igj.v8i3.18170

Samaneh Delavari Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Reza Yazdani Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Hassan Abolhassani Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Fereshte Salami Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Parisa Ashournia Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Aida Askarisarvestani Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Assistant Professor, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Sima Bahrami Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Maryam Behfar Pediatric Cell and Gene Therapy Research Centre, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Hassan Bemanian Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Taher Cheraghi Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran
Kian Darabi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Sepideh Darougar Department of Pediatrics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Sarehsadat EbrahimiEbrahimi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Shabnam Eskandarzadeh Department of pediatrics, Pediatric Health Center, Tabriz University of Medical Sciences, Tabriz, Iran
Golnaz Eslamian Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Narges Eslami Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahrzad Fallah Immunology and Allergy Department, Mofid Children's Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran
Morteza Fallahpour Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Saba Fekrvand Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Ali Haghbin Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran
Zohre Hassanpoor Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Tolue Mahdavi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Homa Hatefi Minaei Dorsa Pharmaceutical Co, Alborz, Iran
Majid Marjani Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahla Mirazizi Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Shariati Street, 67139546581, Kermanshah, Kermanshah, Iran
Mohammadreza Modaresi Pediatric Pulmonary Disease and Sleep Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran, Iran.
Mahshid Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Mohammamd Nabavi Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Mojtaba Ranjbar Children’s Medical Center, Pediatric Center of Excellence, Tehran, Iran
Anahita Razaghian Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Saberi Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahnaz Sadeghi-Shabestari Department of Immunology and Allergy, Tabriz University of Medical Sciences, Tabriz, Iran
Mitra Sahragard Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kiarash Saleki Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
Sahar Seraj Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyedehshabnam Seyedsalehi Abuzar Children’s Medical Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Alireza Shafiei Department of Immunology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
Roya Sherkat Acquired Immunodeficiency Research Center, lsfahan University of Medical Sciences, Isfahan, lran
Reza Shiari Division of Pediatric Rheumatology Department of Pediatrics Mofid Children's Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sima Shokri Department of Allergy and Clinical Immunology, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Saman Tavakoli Department of Pediatric, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Ahmad Vosughimotlagh Immunology and Allergy Department, Mofid Children's Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nima Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran

DOI: https://doi.org/10.18502/igj.v8i3.18170

Keywords: National Consensus; Inborn Errors of Immunity; Chronic Granulomatous Disease; Manage- ment; IFN-γ; HSCT

Abstract

Currently, a national consensus or guideline for diagnosing and managing patients suspected of having chronic granulomatous disease (CGD) is lacking. This consensus is written based on a combination of scien- tific literature and comments from the expert panel of Iranian immunologists. A group of clinical immunol- ogists reviewed the current consensus, presented their comments at a meeting titled “First Meeting on the Diagnosis of Inborn Errors of Immunity (IEI) by IEI Experts” and agreed on this consensus. This consensus guideline provides recommendations on the diagnosis, antimicrobial prophylaxis, management of clinical manifestations, administration of interferon gamma (IFN-γ) and hematopoietic stem cell transplantation (HSCT) for patients with CGD.