Autoimmunity and Fibromyalgia: Common Pathogenesis and Promising Biomarkers

Shakiba Yousefi; Vahid Mansouri

doi:10.18502/igj.v8i2.18000

Shakiba Yousefi Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Vahid Mansouri Gene Therapy Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/igj.v8i2.18000

Keywords: Fibromyalgia; Autoimmunity; Autoimmune Disease; Biomarker; Antibody; Cytokine

Abstract

Fibromyalgia(FM) is a common rheumatologic syndrome with a wide spectrum of symptoms that can be debilitating. In spite of attempts to discover FM pathogenesis, It is still challenging and poorly understood, and there is no reliable biomarker for the diagnosis of FM. Recent studies showed the role of the immune system in the pathogenesis of FM. So, this review focuses on the immunological aspects of FM pathogenesis, including associated autoimmune comorbidities, autoantibodies, and inflammatory cytokines.