Serum Level of Interleukin-17 in Patients with Recurrent Aphthous  Stomatitis

Shamsolmolouk  Najafi; Farzaneh  Bolandparva; Arezou  Rezaei; Mohammad Javad  Kharrazifard; Nima   Rezaei

doi:10.18502/igj.v7i2.17859

Shamsolmolouk Najafi Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Farzaneh Bolandparva Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Arezou Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Javad Kharrazifard Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Nima Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/igj.v7i2.17859

Keywords: Aphthous Stomatitis; Interleukin-17; Inflammation; RAS

Abstract

Background: Recurrent aphthous stomatitis (RAS) is an inflammatory nature, while interleukin 17 (IL-17) has a pre-inflammatory role. In the present study, serum level of IL-17 was measured in a group of individuals with RAS, compared to healthy individuals.
Methods: This case-control study was done on 36 patients with RAS as cases and 36 healthy subjects as controls. The level of IL-17 was measured, using ELISA method.
Results: The mean serum level of IL-17 in cases was 0.14±0.21 pg/ml, which was insignificantly lower than 0.21±0.17 pg/ml in control group (p=0.12). Meanwhile there was a significant reverse correlation between age and serum level of IL-17 (r=-0.32, p=0.006).
Conclusion: Although the serum level of IL-17 in RAS patients was lower than the controls, the difference was not significant. However, significantly lower serum level of IL-17 in older subjects