Long Non-Coding RNAs (lncRNA) Are Key Factors in the Complex Puzzle of Breast Cancer Immunopathogenesis: A Review Study

Mohammad Lotfi; Mohammad-Reza  Mahmoudian-Sani; Mohammad  Saeedi-Sarqaleh; Fatemeh Shojaei-Moghaddam; Haniyeh Saadati-Maleki; Eleheh  Karimzadeh-Soureshjani; Rasoul Saadi; Ali  Saeedi-Boroujeni

doi:10.18502/igj.v6i3.16573

Mohammad Lotfi Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Mohammad-Reza Mahmoudian-Sani Thalassemia & Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Mohammad Saeedi-Sarqaleh Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Fatemeh Shojaei-Moghaddam Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Haniyeh Saadati-Maleki Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Eleheh Karimzadeh-Soureshjani Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Rasoul Saadi Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran
Ali Saeedi-Boroujeni Department of Basic Medical Sciences, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran

DOI: https://doi.org/10.18502/igj.v6i3.16573

Keywords: Breast; Cancer; Immunology; Long-Non-Coding; RNA; Signaling Pathway.

Abstract

Long non-coding RNAs (LnC RNAs) exert a substantial influence on breast cancer by exerting both positive and negative control over signaling pathways. LncRNAs are transcribed similarly to mRNA, however they do not undergo the process of translation to become proteins. Initially, these RNAs were classified as "Junk RNAs" since they were thought to lack any practical use. Comprehensive research has demonstrated that they play a vital role in the progression of various diseases, including malignancies, allergies, autoimmune and autoinflammatory disorders, infectious diseases, cardiovascular disease, and atherosclerosis. Despite multiple efforts, breast cancer continues to be a substantial concern and is one of the most prevalent forms of malignancy, especially among women. Recently, researchers have been dedicated to acquiring a deeper understanding of how complex signaling pathways are controlled by Lnc-RNAs in breast cancer. In the setting of breast cancer, Lnc-RNAs have a contradictory effect. The objective of this study is to Review and categorize previous studies An investigation was conducted to examine the impact of long non-coding RNAs on breast cancer. This will improve the capacity to identify topics of research that require further investigation in future studies.