Effect of a Six Week-Swimming Interval Training with Resveratrol Consumption on Apoptotic Markers in the Liver Tissue of Aged Rat

Maryam Mehboodi; Habib Asgharpour; Seyed Ali  Hosseini; Reza  Rezaeeshirazi

doi:10.18502/ehj.v7i1.6550

Maryam Mehboodi Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran
Habib Asgharpour Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran
Seyed Ali Hosseini Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Reza Rezaeeshirazi Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran

DOI: https://doi.org/10.18502/ehj.v7i1.6550

Keywords: Swimming Training, Resveratrol, Apoptosis, Liver, Aging

Abstract

Introduction: Aging involves a decrease in physiological function, physical activity and nutrition that modulate body functions. The aim of this study was to evaluate the effect of a six week- swimming interval training with resveratrol consumption on apoptotic markers in the liver tissue of aged rat.

Methods: In this experimental study, thirty-two 20-month aged rats weighing 350-370 g were divided into four groups of 8 rats including 1) sham, 2) training, 3) resveratrol and 4) training + resveratrol. For six weeks, groups 3 and 4 received 100 mg/kg of resveratrol supplementation dissolved in 1% methylcellulose daily by gavage, and groups 2 and 4 performed swimming training three times a week. One-way analysis of variance with Tukey's post- hoc test was used to analyze the data (p < 0.05).

Results: Bcl2 Gene expression levels in the resveratrol and the exercise + resveratrol groups were significantly higher than the sham and exercise groups (p < 0.05). Bax levels in the exercise + resveratrol group were lower than the resveratrol group, and the levels in the resveratrol group were higher than the sham group(p <0.05).also Bax/Bcl2 levels in the exercise + resveratrol group were significantly lower than the exercise group(p < 0.05).

Conclusion: It seems that swimming interval training with resveratrol consumption has beneficial effects on anti-apoptotic markers, however, the effect of swimming interval training on liver apoptosis in the aging is still unknown and more studies are needed in this field.