Investigation of Impact of Trinitroglycerin Conjugated Cardioplegia on Myocardial Protection of Patients With Coronary Artery Bypass Grafting

Mohammad Hasan Nemati; Hasan Badie; Mansour Jannati

doi:10.18502/acta.v57i10.3246

Mohammad Hasan Nemati
Hasan Badie
Mansour Jannati

DOI: https://doi.org/10.18502/acta.v57i10.3246

Keywords: Coronary artery bypass graft; Cardioplegia; Trinitroglycerine

Abstract

Pharmacologic-conjugated-cardioplegia is one of the strategies against ischemia and reperfusion. The aim of this study was to investigate the impact of nitroglycerin on myocardial protection and postoperative outcomes. This was a case-control study performed on 91 patients undergoing coronary artery bypass grafting in Faghihi Hospital, Shiraz University of Medical Sciences. Patients were randomly divided into case and control groups. Trinitroglycerin Conjugated Cardioplegia on Myocardial Protection of Patients with Coronary Artery Bypass Grafting. As a result of nitroglycerin, the number of patients requiring inotrope administration was increased. No other significant alteration was observed between two groups in neither of ischemic features nor postoperative outcomes. In conclusion, nitroglycerin conjugated cardioplegia, with the condition of this study, demonstrated a negative inotrope requirement without improvement in myocardium protection. © 2019 Tehran University of Medical Sciences. All rights reserved.