The Relationship Between a Genetic Variant in the HSPB1 Gene and a Lower Risk of Cardiovascular Diseases: The Results of the MASHAD Cohort Study

Authors

  • Fatemeh Sadabadi Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Saberi-Karimian Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hamideh Ghazizadeh Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Moohebati Department of Cardiovascular, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Habibollah Esmaily Department of Biostatistics & Epidemiology, Faculty of Health, Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Sadegh Khorrami Mohebbseraj Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sousan Darroudi Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Zahra Asadi Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Alireza Pasdar Medical Genetics Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Amirhossein Sahebkar Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Alireza Heidari-Bakavoli Department of Cardiovascular, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sara Samadi Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mahmoud Reza Azarpazhooh Department of Clinical Neurological Sciences, Western University, London, ON, Canada
  • Gordon A. Ferns Brighton and Sussex Medical School, Division of Medical Education, Brighton, UK
  • Amir Avan Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Majid Ghayour-Mobarhan Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

DOI:

https://doi.org/10.18502/acta.v64i7.22418

Keywords:

Anti-HSP27 antibody; CHD; HSB1 gene polymorphism; rs2868371

Abstract

Coronary heart disease (CHD) is a leading cause of death, highlighting the importance of risk stratification and prognostic biomarkers in CHD. There is a growing body of evidence supporting the potential value of heat shock proteins (HSPs) in the pathogenesis of atherosclerosis. Here, we explored the relationship between serum anti-HSP27 levels and a genetic variant, rs2868371, in the HSB1 gene in the Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study carried out in Mashhad. A total of 8776 subjects were recruited. Anti-HSP27 levels were measured using an in-house enzyme-linked immunosorbent assay (ELISA), followed by genotyping using a TaqMan® probe-based assay. Demographic, biochemical, and hematological characteristics of the population were evaluated in all subjects. Kaplan-Meier curves were utilized, while logistic regression models were used to evaluate the relationship between genotypic frequencies and clinical characteristics of the population. No significant difference in anti-HSP27 levels was demonstrated between subjects with and without CHD. The frequencies of the CC, CG, and GG genotypes were 68%, 26.8%, and 5.2%, respectively. CAD patients with GG and GC genotypes had a lower risk of myocardial infarction (MI) compared with the reference group after adjusting for confounding factors [OR=0.27 (95% CI=0.08-0.94), P=0.040]. Our data revealed a relationship between the genetic variant in the HSB1 gene and the risk of developing CHD, supporting further research on the potential value of this emerging marker in predicting cardiovascular disease.

Published

2026-08-26

Issue

Volume (64) issue (7)

Section

Articles