Effect of Hydroalcholic Extract of Allium noeanum Reut. ex Regel on Ethylene Glycol- Induced Kidney Stone in Male Wistar Rats

Mehrdad Goudarzi; Maryam  Eskandari Mehrabadi; Zahra Salemi; Jamal Amri; Mitra Noori; Ali Rahbari; Amirhossein Alizadeh; Atefeh Soltani; Mitra Panahi; Farshad Eskandari Mehrabadi

doi:10.18502/tim.v6i3.7304

Mehrdad Goudarzi Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
Maryam Eskandari Mehrabadi Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Zahra Salemi Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Jamal Amri Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
Mitra Noori Department of Biology, Faculty of Sciences, Arak University, Arak, Iran
Ali Rahbari Department of Pathology, Arak University of Medical Sciences, Arak, Iran
Amirhossein Alizadeh Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Atefeh Soltani Department of Medical Sciences, Islamic Azad University, Aligodarz, Iran
Mitra Panahi Department of Biology, Alexander College, Vancouver, Canada
Farshad Eskandari Mehrabadi Islamic Azad University of Ayatollah Amoli, Amol, Iran

DOI: https://doi.org/10.18502/tim.v6i3.7304

Keywords: Allium noeanum extract; Urinary calculim; Ethylene glycol; Rat; Calcium oxalate

Abstract

We want to evaluate the effect of Allium noeanum Reut. ex Regel (Bonsor) known (traditional medicine agent) in calcium oxalate stones in kidney. 36 male rats were divided into 6 groups. I: healthy model + water, II: negative model + 1% ethylene glycol in water, III: 750 mg/kg of total extract +1% of ethylene glycol in water(Prevention), IV: 250 mg/kg flavonoid extract +1% of ethylene glycol in water (Prevention), V: 1500 mg/kg of total extract from 15^th day+ 1% of ethylene glycol in water (Treatment), VI: 500 mg/kg of flavonoid extract from 15^th of the study + 1% of ethylene glycol in water (Treatment).24-hour urine and blood samples were collected in 30th day for analysis. Pathology of kidneys was checked. Serum urea, uric acid, creatinine and urine calcium and oxalate were significantly increased, urine citrate was decreased in group II Vs I. (P < .05). Extract administration significantly decreased serum creatinine, urea and uric acid. Urine calcium and oxalate significantly decreased in treated groups. Urine calcium levels were significantly decreased in treated rats, but urine citrate levels were increased Vs group II. (P < .05). No crystal accumulation and tubular cast were observed in prevention groups. Hydroalcholic extract of Allium noeanum was able to reduce urine oxalate.