Unveiling Antiarthritic Potential of Moringa oleifera Lam. Extract: Evaluation and Hydroxypropylmethylcellulose-Based Formulation

Minakshi Pandey; Meenakshi Bajpai

doi:10.18502/tim.v9i3.16530

Minakshi Pandey Sharda School of Pharmacy, Sharda University, U.P., India
Meenakshi Bajpai Institute of Pharmaceutical Research, GLA University, U.P., India

DOI: https://doi.org/10.18502/tim.v9i3.16530

Keywords: Moringa oleifera; Plant extracts; Anti-arthritic; Hen’s egg albumin; Diclofenac

Abstract

Medicinal plants consist of complex chemical compounds that have been acknowledged for their important role in treating persistent human illnesses. This research concentrates on the phyto-physicochemical evaluation of Moringa oleifera Lam. extract and its in vitro anti-arthritic properties, as determined by inhibiting protein denaturation utilizing varying concentrations of the extract and a standard drug, diclofenac sodium. The study's results revealed a significant in vitro anti-arthritic impact of the extract, with an 85.8% inhibition compared to the standard drug's 99.9% inhibition. Furthermore, this research involved creating sustained-release tablets using hydroxypropyl methylcellulose (HPMC)-based formulations and various grades of hydrophilic polymers along with a fixed quantity of a hydrophobic polymer. The manufactured tablets demonstrated favourable sustained-release traits through direct compression, with the MF2 formulation showing a 73.8% cumulative release over 10 hours.