Electrospun Poly Vinyl Alcohol Fiber Containing Lawsonia inermis L.: A Promising Effect on Burn Wound

Hengameh Dortaj; Sareh Dortaj; Majid Pourentezari

doi:10.18502/tim.v7i3.10767

Hengameh Dortaj Department of Tissue Engineering and Applied Cell Science, Shiraz University of Applied Medical Science and Technologies, Shiraz, Iran
Sareh Dortaj Dubai Pharmacy College, Dubai Medical University, Dubai, United Arab Emirates
Majid Pourentezari Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/tim.v7i3.10767

Keywords: Poly Vinyl Alcohol, L. inermis, Wound dressing, Burn, Electrospinning

Abstract

Henna plant (Lawsonia inermis L.) has unique properties and has long been used as an herbal remedy. In this study, polyvinyl alcohol (PVA) nanofibers containing henna extract in two different concentrations were studied to prepare a wound dressing using electrospinning. PVA polymer nanofibers using henna extract with two different concentrations of 3% and 6% were prepared by the electrospinning method. Human fibroblasts were cultured on these fibers and the mechanical and survival properties of the cells, as well as the antibacterial properties of henna were compared and evaluated. The results showed that by using of henna extract in PVA nanofibers, cell viability was significantly reduced (P≤0.05). However, the ability of nanofibers to water uptake and mechanical properties of fibers significantly increased with increasing concentrations of henna extract (P≤0.05). Nanofiber wound dressing with antibacterial properties of henna extract provides relatively fast and rapid wound healing ability. The resulting fibers are encouraging candidates for the development of improved bandaging materials.