Is there an Association between Side Effects of AstraZeneca, Sputnik, Covaxin and Sinopharm COVID-19 vaccines and Breakthrough Infections?

Amirsaleh Abdollahi; Iman Naseh; Fatemeh Kalroozi; Mohammad Hassan  Kazemi-Galougahi; Maryam Nezamzadeh; Mehran Frouzanian; Maryam Feyzollahi; Mojtaba Yousefi- zoshk

doi:10.18502/tbsrj.v4i2.9662

Amirsaleh Abdollahi School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Iman Naseh Department of Infectious Diseases, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Fatemeh Kalroozi Department of Pediatric Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
Mohammad Hassan Kazemi-Galougahi Department of Social Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Maryam Nezamzadeh Department of Critical Nursing, School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
Mehran Frouzanian School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Maryam Feyzollahi School of Nursing, AJA University of Medical Sciences, Tehran, Iran.
Mojtaba Yousefi- zoshk Department of Pediatrics, School of Medicine, Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.

DOI: https://doi.org/10.18502/tbsrj.v4i2.9662

Keywords: Adverse event; Breakthrough infections; COVID-19; Vaccines

Abstract

Introduction: Safe and efficacious vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), would contribute to contain the COVID-19 pandemic. In this study, we examined this question that if there is an association between the incidence of side effects and the COVID-19 breakthrough infections.

Material and Methods: This descriptive-analytical cross-sectional study was conducted for two months from June 22 to August 22, 2021. The study method was complete enumeration and 1474 healthcare workers who were medical staff of seven hospitals in Tehran and were vaccinated with one of the AstraZeneca, Covaxin, Sputnik V, and Sinopharm vaccines. Two main questions of this questionnaire were the occurrence or non-occurrence of any side effects after receiving the vaccines and the presence or absence of COVID-19 infection after vaccination.

Results: According to the results obtained, in recipients vaccinated with Sinopharm vaccine, the group that reported at least one side effects after receiving the vaccine had a significantly higher COVID-19 infection than the group reported no side effects after vaccination (P<0.001) (RR=4.55). Also in whole sample study Participants who have reported one or more side effect after COVID-19 vaccination, had 3.7 times higher risk of breakthrough infection than others (P<0.001); However Among those vaccinated with AstraZeneca, Covaxin and Sputnik vaccines, no significant difference was observed between the groups with and without side effects after vaccination in terms of later COVID-19 infection.

Conclusion: It seems that participants who have reported one or more side effect after COVID-19 vaccination, had times higher risk of breakthrough infection than others.