Evaluation of Zinc Supplement on Biochemical Parameters among Pulmonary Tuberculosis Patients

Bahareh Zolfaghari; Parisa Mohamadi; Solmaz Morsali; Azita Aliakbarniya; Zohreh Nasiri; Massoumeh Hotelchi

doi:10.18502/tbsrj.v3i2.6669

Bahareh Zolfaghari Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Parisa Mohamadi Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Solmaz Morsali Department of Biology, Molecular genetics Branch, Islamic Azad university, Ahar, Iran.
Azita Aliakbarniya Department of Biology, School of Life Sciences, Tonekabon Branch, Islamic Azad University, Mazandaran, Iran.
Zohreh Nasiri Department of Clinical Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Massoumeh Hotelchi Department of Clinical Biochemistry‚ School of Medicine‚ Shahid Beheshti University of Medical Sciences‚ Tehran‚ Iran.

DOI: https://doi.org/10.18502/tbsrj.v3i2.6669

Keywords: Antituberculosis Drug, Pulmonary Tuberculosis, Zinc

Abstract

Introduction: Zinc (Zn) is an essential micronutrient in humans, and its deficiency is reported in many disorders, including tuberculosis (TB). The current study's goal is to evaluate the anti-TB effect of Zn supplementation among pulmonary tuberculosis patients.

Material and Methods: In this study, 74 newly diagnosed tuberculosis patients referred to Qom Health Center were distributed into two groups of receiving 50 mg of zinc sulfate and placebo. All patients in both groups received the same antituberculosis antibiotics. Before starting treatment and after two and six months of treatment with antituberculosis drugs, the serum levels of zinc and biochemical parameters were measured by atomic absorption spectrophotometry and a RA1000 Auto Analyzer, respectively.

Results: After two months of treatment, the serum Zn concentration in the Zn receiving group was higher than the placebo group. After anti-TB treatment, body mass index (BMI) and serum albumin were significantly higher than pretreatment in both groups. The serum alkaline phosphatase changes, uric acid, creatinine, and urea were not significantly different in both groups at different times.

Conclusion: The supplementation of Zn micronutrient results in improved BMI, serum Zn, and other biochemical parameters compared to before treatment.