Risk Factors of Osteoporosis in Females: A Hospital-Based Case-Control Study, Yazd, Iran

Maryam  Askari; Mohammad Hassan  Lotfi; Mohammad  Azimi; Maral  Ostovarfar; Hossein  Fallahzadeh; Akram  Mehrabbeik; Andishe  Hamedi

doi:10.18502/ijph.v51i6.9693

Maryam Askari Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Med-ical Sciences, Yazd, Iran
Mohammad Hassan Lotfi Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad Azimi Department of Occupational Health, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Abarkouh, Yazd, Iran
Maral Ostovarfar Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hossein Fallahzadeh Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics Nand Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Akram Mehrabbeik Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Med-ical Sciences, Yazd, Iran
Andishe Hamedi Faculty of Epidemiology & Biostatistics, Imam Khomeini Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran

DOI: https://doi.org/10.18502/ijph.v51i6.9693

Keywords: Osteoporosis; Women; Case-control study; Iran

Abstract

Background: The aim of this study was to evaluate the predictors of osteoporosis in women in Yazd, Iran.

Methods: This hospital-based case-control study was performed on 270 women 35-65 yr old (135 case and 135 control) from Mar 2016 to Mar 2017. Case and control were matched in terms of age ± 2 (year) as a group matching. Osteoporosis is defined as a T-score of bone mineral density (BMD) below –2.5 SD. Data were analyzed using SPSS 20 software. Statistical tests included chi-square, student t test and Mann Whitney test .Multiple logistic regression (MLR) which forward method was used for modeling.

Results: Odds ratio (OR) of osteoprosis were menarche age>12 yr (OR=3.37, CI:2.29-15.89), history of hysterectomy (OR=13, CI:3.81-44.82), rheumatoid arthritis (RA) (OR=6.58, CI:2.29-18.91) calcium supplements (OR=0.14, CI:0.04-0.41), menopause age <40 (OR=11.84, CI:1.54-90), second smoking (OR=3.38, CI:1.16-9.81) and increase of weight (OR=0.86, CI:0.80-0.94).

Conclusion: Predictors of osteoporosis was menarche age >12 yr (3 times), history of hysterectomy (13 times), RA (6.5 times), menopause age <40 (12 times), second smoking (more than 3 times), calcium supplements and weight (protective).