Graft and Patient Survival Rate among Iranian Pediatric  Recipients of Kidney Transplantation:  A Systematic Review and Meta-Analysis

Ahmad  Shajari; MohammadMoein  Ashrafi; Hamideh  Shajari; Ali  Derakhshan

doi:10.18502/ijph.v51i6.9666

Ahmad Shajari Ali-Ebne-Abitaleb School of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
MohammadMoein Ashrafi Young Researchers and Elites Club, Faculty of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
Hamideh Shajari Department of Neonatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran,Iran
Ali Derakhshan Shiraz Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/ijph.v51i6.9666

Keywords: Kidney transplantation; End stage renal disease; Graft survival; Patient survival; Meta-analysis

Abstract

Background: The End Stage Renal Disease (ESRD) is irreversible impairment of renal function, to the extent that the patient becomes permanently dependent on alternative therapies, especially in children. We aimed to evaluate the graft and patient survival rate among iranian pediatric recipients of kidney transplantation through a systematic review and meta-analysis.

Methods: National (SID, MagIran, IranMedex, IranDoc) and international (Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science) databases of, were searched to find studies published electronically from 1985 until Nov 2019. Heterogeneity between the collected studies was determined using the Cochran’s test (Q) and I². Meta-regression was used to investigate the factors affecting statistical heterogeneity in 1, 5, and 10-year survival of kidney transplantation in addition to subgroup analysis based on cities.

Results: Ten studies were qualified to enter the meta-analysis. The total participants in the study were 2673 people with an average age of 13.71±3.65 years. In the random-effects model, the survival rate of 1, 3, 5 and 10 yr of kidney transplantation were 91, 88, 81 and 70%, respectively.

Conclusion: By providing the documented and comprehensive evidence, can be the basis of many plans, policies, and decisions of various sectors of development. These sectors include the evaluation of treatment programs and health interventions in the pediatric kidney transplantation. The results of the present study can provide an acceptable estimate of the survival rate of transplanted children in Iran and will be useful for planning prevention and treatment programs.