Metagenomic Next-Generation Sequencing for the Diagnosis of Epstein-Barr virus Pleurisy: A Case Report

Hui Lv; Jin Liu; Ruoyu Zhang

doi:10.18502/ijph.v50i11.7589

Hui Lv Department of Geriatrics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China
Jin Liu Department of Geriatrics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China
Ruoyu Zhang Department of Geriatrics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China

DOI: https://doi.org/10.18502/ijph.v50i11.7589

Keywords: Metagenomic next-generation sequencing; Chronic active Epstein-Barr virus infection; Viral pleurisy

Abstract

Chronic active Epstein-Barr virus infection (CAEBV) progresses rapidly in the later stage and has a poor prognosis. The treatments of CAEBV have no unified standard and a bad effect. Only few person could cure. It is important to diagnosis early. Metagenomic next-generation sequencing (mNGS) offers an effective means for the diagnosis of difficult, critical and rare pathogenic microbial infections. Here, we report a case of viral pleurisy caused by CAEBV identified by mNGS in an 88-year-old Chinese male patient.