Efficacy of Shenqi Jiangtang Granules-Assisted Western Medi-cine in the Treatment of Gestational Diabetes Mellitus (GDM)

Juan  Tang; Li  Fan; Chunlei  Lv; Runjie  Wan; Jianjian  Liu; Xiaoyan Liu

doi:10.18502/ijph.v50i11.7573

Juan Tang International Medical Services, Qilu Hospital of Shandong University, Jinan 250012, China
Li Fan Jinan Lixiaqu Municipal Center For Disease Control and Precention, Jinan 250100, China
Chunlei Lv Operation Room, The Affiliated Hospital of Shandong University of TCM, Jinan 250011, China
Runjie Wan Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China
Jianjian Liu Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China
Xiaoyan Liu Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China

DOI: https://doi.org/10.18502/ijph.v50i11.7573

Keywords: Shenqi Jiangtang granules; Gestational diabetes mellitus; Clinical efficacy; Adverse pregnancy outcome

Abstract

Background: We aimed to investigate the efficacy of Shenqi Jiangtang granules-assisted Western medicine in the treatment of gestational diabetes mellitus (GDM).

Methods: A total of 147 patients with GDM treated in Qilu Hospital of Shandong University from Jan 2018 to Apr 2019 were enrolled. They were randomly divided into traditional Chinese medicine (TCM) combined with Western medicine group, Western medicine group and control group. The control group was treated with exercise combined with diet therapy, and the Western medicine group was additionally treated with metformin tablets. The TCM combined with Western medicine group was additionally treated with Shenqi Jiangtang granules.

Results: After treatment, the levels of 10 indicators in the three groups were lower than those before treatment (P < 0.05). These indicators were the lowest in the TCM combined with Western medicine group. However, high-density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) after treatment increased in the three groups compared with those before treatment (P < 0.05), which was the most obvious in the TCM combined with Western medicine group. After treatment, the number of patients with natural delivery in the TCM combined with Western medicine group was the largest. The incidences of complications in pregnant women, fetuses and newborns were the lowest in the TCM combined with Western medicine group.

Conclusion: Application of Shenqi Jiangtang granules-assisted Western medicine in patients with GDM can effectively control blood glucose and lipid levels, enhance antioxidant capacity, reduce the levels of inflammatory cytokines and decrease the incidence of adverse pregnancy outcomes.