Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis

  • Fatemeh Esfahanian Department of Endocrinology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  • Mojgan Mirabdolhagh Hazaveh Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Laya Hooshmand Garehbagh Department of Endocrinology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  • Kowsar Falahati Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  • Mitra Ataei Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  • Mohammad Hossein Sanati Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  • Zohreh Jadali Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
DOI: https://doi.org/10.18502/ijph.v50i8.6817
Keywords: Mitochondrial DNA; Hashimoto's thyroiditis; Oxidative stress; Autoimmunity

Abstract

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC).

Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018.

Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group.

Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.

Published
2021-07-28
Issue
Volume (50) issue (8)
Section
Articles