Efficacy Evaluation on the Color Doppler Ultrasound, Multislice Spiral CT Combined with Serum Markers in Diagnosis of  Primary Hepatic Carcinoma

Xiaolan  Zhao; Yifang  Xia; Chunjing  Li; Dapeng  Wang

doi:10.18502/ijph.v50i8.6806

Xiaolan Zhao Department of Ultrasound, Yantaishan Hospital, Yantai 264000, China
Yifang Xia Department of Imaging, Zhangqiu District People’s Hospital, Jinan 250200, China
Chunjing Li Department of Imaging, Zhangqiu District People’s Hospital, Jinan 250200, China
Dapeng Wang Department of Imaging, the Affiliated Hospital of China University of Petroleum (East China), Qingdao 266580, China

DOI: https://doi.org/10.18502/ijph.v50i8.6806

Keywords: Primary hepatic carcinoma; Ultrasound; Multislice Spiral CT; Alpha-fetoprotein receptor; Combina-tion examination

Abstract

Background: The efficacy of color Doppler ultrasound, multislice spiral CT combined with serum alpha-fetoprotein (AFP) and alpha-fetoprotein heterogeneity (AFP-L3) in the diagnosis of primary hepatic carcinoma was evaluated.

Methods: Seventy-nine patients with primary hepatic carcinoma (PHC group) and 50 patients with benign liver lesions (benign control group) admitted in Yantaishan Hospital (Yantai, China) from January 2016 to December 2018 were selected. The liver was scanned by color Doppler ultrasound and multiple multislice spiral CT. The serum AFP and AFP-L3 levels were detected by electrochemiluminescence. The value of color Doppler ultrasound, multislice spiral CT combined with serum AFP and AFP-L3 in diagnosis of primary liver cancer was retrospectively analyzed.

Results: The color Doppler flow imaging (CDFI) showed a high-speed and high-resistance spectrum. The serum AFP and AFP-L3 levels of patients with primary hepatic carcinoma were significantly higher than those of the benign control group were (U=138.000 and 155.500, P=0.000 and 0.000), P<0.01. The sensitivity, accuracy and negative predictive value of color Doppler ultrasound, multislice spiral CT combined with serum AFP and AFP-L3 examinations for diagnosis of primary hepatic carcinoma were 96.20, 90.70 and 93.18%, which was significantly improved compared with each single examination (X₂=27.888, 17.511 and 16.202, P=0.000, 0.002 and 0.003), P<0.01.

Conclusion: Color Doppler ultrasound, multislice spiral CT combined with AFP and AFP-L3 examination could significantly improve the diagnosis efficiency of primary hepatic carcinoma, which was beneficial to early clinical diagnosis and early treatment.