Population Attributable Risk of Hyperuricemia in Hypertension  Incidence in 20-74-Year-Old Population during a 10-Year  Longitudinal Cohort: Yazd Healthy Heart Cohort

Mojtaba  MOHAMMADHOSEINI; Seyedeh Mahdieh  NAMAYANDEH; Hosein FALLAHZADEH; Fatemeh  MAJIDPOUR; Seyed Mahmoud  SADR-BAFGHI; Mohammadhosein  SOLTANI; Leila  HADIANI; Mohammadtaghi  SAREBANHASSANABADI; Hossein  NOUGH; Ahmad  KARIMI; Maryam  ASKARI

doi:10.18502/ijph.v49i10.4703

Mojtaba MOHAMMADHOSEINI
Seyedeh Mahdieh NAMAYANDEH
Hosein FALLAHZADEH
Fatemeh MAJIDPOUR
Seyed Mahmoud SADR-BAFGHI
Mohammadhosein SOLTANI
Leila HADIANI
Mohammadtaghi SAREBANHASSANABADI
Hossein NOUGH
Ahmad KARIMI
Maryam ASKARI

DOI: https://doi.org/10.18502/ijph.v49i10.4703

Abstract

Background: The population attributable risk (PAR) percent has used widely in public health policy. We aimed to calculate the attribute risk of hypertension due to hyperuricemia by Levin's formulas compare to direct PAR calculation method.

Methods: This was a sub-study of Yazd Healthy Heart Cohort (YHHC). Overall, 1256 normotensive individuals were enrolled through multistage randomized cluster sampling and followed up for mean 9.8 years, from 2005-2015. The threshold cutoff point of the hyperuricemia was considered equal and more than 75^th percentile that equal to 5.5 mg/dl for men and 4.3mg/dl for women. To calculate the attributable risk of hyperuricemia in developing hypertension, two methods were applied. Levin's formulas and direct PAR estimation by population risk calculation via exposure prevalence weighted formula. Multiple logistic regression was used for estimate of odds ratio (OR) of hyperuricemia in developing hypertension. We calculated Relative Risk (RR) from OR. The data were analyzed using SPSS software version 16. A significant level of 0.05 was considered.

Results: Hypertension developed in 44.7% of individuals with uric acid level ≥ 75^th percentile vs. 35.6% of other individuals (P=0.024). Attributable risk (AR) of hyperuricemia in hypertension incidence was 9.1%. PAR of hyperuricemia for hypertension incidence by using two methods mentioned before was 6%, 5.8% respectively.

Conclusion: The results of the study confirmed the noticeable contribution of hyperuricemia as an independent other risk factor for the occurrence of hypertension. PAR of hyperuricemia for hypertension incidence by using two methods almost near was 6%, 5.8% respectively.