Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

Sima SABBAGH; Zakiye NADEALI; Vahid SHAYGANNEJAD; Majid REZVANI; Masih SABOORI; Hamid GANJI; Soheil TAHANI; Farzaneh DEHGHANI; Saman HOSSEINZADEH; Elnaz MARZBANI; Peiman SHAFIEI

doi:10.18502/ijph.v48i9.3030

Sima SABBAGH
Zakiye NADEALI
Vahid SHAYGANNEJAD
Majid REZVANI
Masih SABOORI
Hamid GANJI
Soheil TAHANI
Farzaneh DEHGHANI
Saman HOSSEINZADEH
Elnaz MARZBANI
Peiman SHAFIEI

DOI: https://doi.org/10.18502/ijph.v48i9.3030

Keywords: Multiple sclerosis; MMP-9 gene; Polymorphism; Association study

Abstract

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.