Determining the Effectiveness of Preventive Measures in  Reducing Intravenous Injection and Catheter-Related Infections: A Meta-Analysis

Huan  Zhang; Jiahuan  He; Feifei  Ke; Miao  Li; Wenjia  Yao

doi:10.18502/ijph.v54i12.20813

Huan Zhang Endocrinology Department, Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Chongqing, China
Jiahuan He Thyroid and Breast Surgery, Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Chongqing, China
Feifei Ke Department of Thoracic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China
Miao Li Military Medical Center, the First Affiliated Hospital of AFMU, No.127, Xian, Shanxi, China
Wenjia Yao Department of Thoracic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China

DOI: https://doi.org/10.18502/ijph.v54i12.20813

Keywords: : Intravenous infections prevention; Patient safety; Healthcare interventions; Infection control; Meta-analysis

Abstract

Background: We aimed to evaluate the efficacy of preventative strategies targeted at lowering these injections.

Methods: A comprehensive assessment of electronic databases (PubMed, Web of Science, and Cochrane Library) was carried out to discover relevant papers published from 2013-2024. Inclusion criteria were randomised controlled trials, quasi-experimental studies, and observational research on therapy for intravenous injection and catheter-related infections. The primary outcome examined was the incidence or prevalence of infections caused by intravenous injections. According to preliminary data from 31 studies, preventive interventions dramatically reduce the incidence of intravenous injection and catheter-related infections. Subgroup analyses indicate effectiveness differences depending on intervention type and patient variables.

Results: Chlorhexidine-based therapies can lower infection risk by 29% (Risk Ratio: 0.71), but taurolidine provides a statistically significant 53% benefit (RR = 0.47). The total risk ratio varies from 0.71 to 0.84, indicating a 29% reduction in infection rates in nations having Needlestick Safety and Prevention Acts. In contrast, the absence of such regulation may result in a 6% to 8% rise in infection rates (RR = 0.96).

Conclusion: Preventative interventions, notably chlorhexidine and taurolidine, can considerably reduce the risk of intravenous injection and catheter-related infections. Chlorhexidine may lower the risk of infection by 29%, whereas taurolidine reduces it by 53%. Nations with Needlestick Safety and Prevention Acts may expect a one-third reduction in infection rates. Conversely, the absence of such laws may result in a significant rise in infection rates.