Safety and Efficacy of Shaoyao Decoction with Anti-Inflammatory Effect in the Treatment of Ulcerative Colitis: A Meta-Analysis

Yan  Zhu; Quanxi  Liu

doi:10.18502/ijph.v54i3.18241

Yan Zhu Department of Gastroenterology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100039, China
Quanxi Liu Department of Gastroenterology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100039, China

DOI: https://doi.org/10.18502/ijph.v54i3.18241

Keywords: Ulcerative colitis; Shaoyao decoction; Meta-analysis

Abstract

Background: We aimed to evaluate the effectiveness and safety of Shaoyao Tang in treating ulcerative colitis (UC) through a randomized controlled meta-analysis.

Methods: Computer searches were conducted between Jan 2000 and Mar 2023 using the databases of CNKI, VIP, PubMed, the Cochrane Library, Wanfang and Web of Science in search of trials with randomization and control including Shaoyao decoction in UC. After quality assessment, The Revman 5.3 was applied.

Results: Overall, 23 articles were selected for the study totally. Shaoyao decoction improved clinical effective rate (P<0.001) and effective rate of syndrome (P<0.001), IBDQ (P<0.001), interleukin-4 (P<0.001) and interleukin-10 (P<0.001), reduced adverse reactions (P=0.004), recurrence rate (P=0.03), DAI (P<0.001), tumour necrosis component α (P<0.001), interleukin-1β (P<0.001), interleukin-6 (P<0.001), and extremely sensitive C-reactive protein (P=0.02).

Conclusion: Shaoyao decoction has certain advantages and good safety in the treatment of UC; however the findings still need to be supported by excellent studies.