The Association between Healthy Eating Index-2015 and Serum Metabolic Parameters in Women with Gallstone Disease:  A Case-Control Study

Moloud  Ghorbani; Amir  Sadeghi; Mohammad  Asghari-Jafarabadi; Beitullah  Alipour

doi:10.18502/ijph.v53i5.15595

Moloud Ghorbani Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Sadeghi Department of Adult Gastroenterology and Hepatology, School of Medicine, Shahid Beheshti University of Medical Sciences, Teh-ran, Iran
Mohammad Asghari-Jafarabadi Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Beitullah Alipour Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

DOI: https://doi.org/10.18502/ijph.v53i5.15595

Keywords: Gallstone disease; Common bile duct stone; Healthy eating index-2015; Metabolic parameters

Abstract

Background: One of the most prevalent gastrointestinal tract ailments is gallstone disease (GD). Diet has been acknowledged as a modifiable GD risk factor. The Healthy Eating Index (HEI) is a scale for evaluating the quality of diets; therefore, this study aimed to determine whether the HEI-2015 score was associated with serum metabolic parameters in women with GD.

Methods: This case-control study was conducted on a sample of 75 women diagnosed with GD and 75 healthy women at the Gastroenterology and Hepatology Clinic of Shahid Beheshti University of Medical Science in Tehran, Iran. Standard laboratory methods were employed to measure the biochemical parameters. The participants' habitual dietary intake was assessed using a validated food frequency questionnaire (FFQ). The HEI-2015 score was computed for all participants. The study employed multivariate logistic regression to identify the optimal predictor of GD. The Pearson Correlation was employed to determine the correlation between the HEI-2015 and serum metabolic parameters.

Results: The study found a significant negative association between the risk of GD and serum HDL-c (OR: 0.84; 95% CI: 0.76–0.95, P=0.008). Moreover, a significant positive association was detected between HOMA-IR (OR: 3.27; 95% CI: 1.16-9.19, P=0.025), and the risk of GD. The study did not find a statistically significant correlation between the HEI-2015 and serum parameters.

Conclusion: While an association was discovered between certain serum metabolic parameters and the risk of GD, the results do not provide a significant association between serum metabolic parameters and HEI-2015 score.