The Relationship between the Permanent Trigeminal Artery and Cerebrovascular Disease: A Meta-Analysis

Jingyan  Zhang; Yan  Wang; Yongliang  Gai; Hanmei  Cui; Bo  Liu; Jie  Li; Yuguang Wang; Juncheng Lv; Shaosen  Chen

doi:10.18502/ijph.v53i5.15579

Jingyan Zhang Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Yan Wang Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Yongliang Gai Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Hanmei Cui Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Bo Liu Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Jie Li Three Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Yuguang Wang CT Room, the Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Juncheng Lv Six Departments of Introneurosis, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Shaosen Chen Thoracic Surgery Department, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China

DOI: https://doi.org/10.18502/ijph.v53i5.15579

Keywords: Permanent trigeminal artery; Cerebrovascular disease; Variability; Internal carotid artery; Basilar artery

Abstract

Background: We aimed to analyze the variability of the permanent trigeminal artery (PTA) and its relationship with cerebrovascular disease.

Methods: To analyze the variability of the PTA and its relationship with cerebrovascular disease by using the terms "primitive trigeminal artery", "persistent primitive trigeminal artery", " persistent trigeminal artery variant", "PPTA", "PTAV", "carotid- basilar anastomoses", "carotid-vertebrobasilar anastomoses", "persisting embryonic vessels" were used as keywords, and the English-language literature related to PTA and cerebrovascular diseases published in PubMed, EMBAS, and Web of Science databases from 2000 to 2022 were searched by using "subject terms + free words". A meta-analysis of the collected data was performed using stata14.0 statistical software to assess the relationship between the immortal trigeminal artery and cerebrovascular-related diseases.

Results: A total of 1908 relevant articles were initially retrieved for this study. Ten papers were initially screened according to the inclusion and exclusion criteria, while the literature was then read one by one to exclude duplicates, reviews, case reports, and conference abstracts, and six papers were finally included for meta-analysis. The six papers included in this paper were all cross-sectional studies with 39,355 subjects, of which 206 subjects had PTA, with a variation rate of approximately 0.52%, including 77 males and 129 females, 117 left-sided variants and 87 right-sided variants. In contrast, of the 206 subjects with a PTA, 52 had cerebrovascular disease, with an overall prevalence of approximately 25.24%.

Conclusion: The PTA could influence the development of cerebrovascular disease.