The Trend of Years of Life Lost due to Gastrointestinal Cancers in Fars (Iran) 2004-2019

Habibollah  Azarbakhsh; Seyed Sina  Dehghani; Jafar  Hassanzadeh; Amir Hossein  Hassani; Maryam  Janfada; Alireza  Mirahmadizadeh

doi:10.18502/ijph.v53i3.15149

Habibollah Azarbakhsh Department of Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Seyed Sina Dehghani Social Medicine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Jafar Hassanzadeh Department of Epidemiology, Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shi-raz, Iran
Amir Hossein Hassani Social Medicine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Janfada Non-Communicable Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Alireza Mirahmadizadeh Non-Communicable Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/ijph.v53i3.15149

Keywords: Gastrointestinal; Cancer; Years of life lost; Iran; Joinpoint regression

Abstract

Background: Gastrointestinal cancers can cause major health problems globally since their burden is increasing in many countries. We aimed to investigate the trend of years of life lost due to gastrointestinal cancers in Fars Province, southern Iran during the 2004-2019.

Methods: In this cross-sectional survey study, we obtained the information regarding all deaths due to gastrointestinal cancers in Fars Province from the electronic population-based death registration system (EDRS). Years of Life Lost (YLL) was calculated using the YLL template of 2015 by the WHO. To examine the trend for different years, join point regression based on the log-linear model was used. Joinpoint regression analysis describes changing trends over successive periods of time and the increasing or decreasing rate within each period.

Results: During the years of 2004-2019, 9742 deaths due to gastrointestinal cancers occurred in Fars Province. 6013 (61.72%) cases were male and 3729 (38.28%) cases were female (Male / Female Sex Ratio: 1.61). Overall, 4152 cases (42.63%) were due to gastric cancer and 2112 cases (21.68%) were due to liver cancer. Total years of life lost due to premature death from gastrointestinal cancers during the 16-year study period was 73565 yr (2.33 per 1000 persons) in men, 52766 yr (1.71 per 1000 persons) in women, and 126331 yr (2.02 per 1000 persons) in both sexes.

Conclusion: Among all cancers, the highest mortality rates in both sexes belong to gastric cancer. This study showed the trend of YLL rate of malignant neoplasms of liver and intrahepatic bile ducts, esophagus, oral cavity, and colon cancer were increasing in both sexes, however, the trend of YLL rate for malignant neoplasms of the small intestine was decreasing in both sexes. Variation of GI cancers patterns and trends around the Fars Province indicated that a more comprehensive control plan is needed to control these variations.