Role of Thulium Laser and Holmium Laser in the Surgical Treatment of Benign Prostatic Hyperplasia: A Systemic Review and Meta-Analysis

Jin Wang; Shikui Wu; Mingsheng Wang

doi:10.18502/ijph.v53i3.15131

Jin Wang Department of Urology, The First Hospital of Xuzhou Mining Group, Xuzhou, 221131, China
Shikui Wu Department of Urology, The First Hospital of Xuzhou Mining Group, Xuzhou, 221131, China
Mingsheng Wang Department of Urology, The First Hospital of Xuzhou Mining Group, Xuzhou, 221131, China

DOI: https://doi.org/10.18502/ijph.v53i3.15131

Keywords: Benign prostatic hyperplasia; Holmium laser; Thulium laser; Treatment

Abstract

Background: Patients with benign prostatic hyperplasia are generally treated holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP). Therefore, it is important to analyze the several surgical procedures used for benign prostatic hyperplasia in terms of their role, effectiveness and safety.

Methods: We conducted a meta-analysis by searching databases of PubMed, Google Scholar, and Web of Science. Finally, we selected 10 papers including 2,456 patients treated with of thulium laser and holmium laser in the surgical treatment of benign prostatic hyperplasia. We did the analysis using RevMan 5.0 with the selected studies until 26 October 2023.

Results: ThuLEP resulted in a smaller reduction in haemoglobin (MD: -0.22, 95%CI -0.32 to -0.13, P<0.001) and a shorter hospital stay (MD: -0.29, 95%CI -0.38 to -0.20, P <0.001). During the postoperative follow-ups, only the IPSS (MD: -0.03; 95%CI -0.11 to -0.06; P 0.58) at the six-month showed statistically significant differences.

Conclusion: ThuLEP has greater security and faster growth than HoLEP.