Gamma-Aminobutyric Acid Type A Receptor Subunit Delta (GABRD) Inhibits Breast Cancer Progression by Regulating the Cell Cycle

Liang  Wu; Yue  Zhang; Chunlei  Zheng; Fuqiang  Zhao; Yan  Lin

doi:10.18502/ijph.v52i3.12137

Liang Wu Department of Emergency Surgery, the Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
Yue Zhang Section of Chinese as a Foreign Language, International Education School, Qiqihar Medical University, Qiqihar 161006, China
Chunlei Zheng Department of Surgical Oncology, the Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
Fuqiang Zhao Department of Surgical Oncology, the Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
Yan Lin Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar 161006, China

DOI: https://doi.org/10.18502/ijph.v52i3.12137

Keywords: γ-aminobutyric acid receptor; Breast cancer; Prognosis; Growth; Cell cycle

Abstract

Background: The role of γ-aminobutyric acid receptor (GABR) in breast cancer (BC) is unknown.

Methods: The expression of different GABR subunits between BC and adjacent normal tissues was compared using transcriptome data set. The clinical and prognostic importance of the various GABR subunit genes in BC was determined using clinical and survival data (Data downloaded from TCGA, May 2022). Only GABRD was discovered to be substantially expressed and strongly related to the prognosis of BC cases.

Results: Compared with normal tissues, GABRD expression was increased in all subgroups of breast cancer tissues. Knockdown of GABRD inhibited the growth of BC cells. Mechanistically, the function of GABRD may be attributed to its effect on major pathways such as oxidative phosphorylation, Parkinson disease, and cell cycle. GABRD deletion significantly blocked the G2/M phase in BC cells.

Conclusion: Overall, GABRD might be a novel prognostic predictor of BC, providing clues for further studies on GABRD.