Health-Related Quality of Life in Patients with Chronic Hepati-tis B: A Meta-Analysis of Observational Studies

Saniya  Saussakova; Gaukhar  Dauletova; Zhandulla  Nakipov; Gulzat  Sarsenbayeva; Samal  Duisekova; Zhanat  Sadibekova; Karlygash  Raissova; Assiya  Turgambayeva

doi:10.18502/ijph.v52i3.12129

Saniya Saussakova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Gaukhar Dauletova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Zhandulla Nakipov Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Gulzat Sarsenbayeva Department of Medical Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Samal Duisekova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Zhanat Sadibekova Department of Social Health Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Karlygash Raissova Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Assiya Turgambayeva Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan

DOI: https://doi.org/10.18502/ijph.v52i3.12129

Keywords: Quality of life; Health-related quality of life; Chronic hepatitis B patients; Meta-analysis

Abstract

Background: Chronic hepatitis B virus (CHB) infection is one of the most common liver infections worldwide. Approximately 240 million patients are diagnosed with CHB. The objective of this meta-analysis was to identify the effect of CHB on the affected patients’ health-related quality of life and compare with the control group.

Methods: A comprehensive search was conducted through PubMed, Medline, ProQuest, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Web of Science databases up to Jul 2022.

Results: Five primary observational studies using SF-36 and WHOQOL surveys with 1135 participants (646 with CHB and 489 healthy individuals) included in the meta-analysis. We evaluated the scores of physical and mental component summaries. HRQoL was comparable in both groups. The disease's impact appears to slightly affect the mental component summary than the physical component summary.

Conclusion: The HRQoL in CHB patients is mainly reflected in the impairment of the mental aspect. It is vital to focus on optimally managing care, family and social support, stress management.