Survival Rate of Liver Transplantation in Asia: A Systematic  Review and Meta-Analysis

Mousa  Ghelichi-Ghojogh; Abdolhalim  Rajabi; Fateme  Mohammadizadeh; Layla  Shojaie; Mouhebat  Vali; Sima  Afrashteh; Soheil  Hassanipour; Hossein-Ali  Nikbakht; Rozhan  Khezri; Ehsan Allah  Kalteh; Mohammad  Fararouei

doi:10.18502/ijph.v51i10.10979

Mousa Ghelichi-Ghojogh Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolhalim Rajabi Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
Fateme Mohammadizadeh Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Layla Shojaie Division of GI/Liver, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Mouhebat Vali Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Sima Afrashteh Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Soheil Hassanipour Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Hossein-Ali Nikbakht Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Rozhan Khezri Urmia Health Center, Urmia University of Medical Sciences, Urmia, Iran
Ehsan Allah Kalteh Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Mohammad Fararouei HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/ijph.v51i10.10979

Keywords: Liver transplantation; Survival analysis; Meta-analysis; Asia

Abstract

Background: Liver transplantation is one of the most effective treatments for acute liver failure, chronic liver cirrhosis, and hepatocellular carcinoma. This study was implemented to evaluate the survival rate of liver transplant in Asia.

Methods: Studies that investigated the survival rate of liver transplant were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane to Nov 30th, 2020. Pooled survival rate and 95% confidence intervals were calculated using Der-Simonian and Laird method. Stata 16.0 (Stata Corp, College Station, TX, USA) was used for analysis.

Results: One, 2, 3, 5, and 10-year survival rates of liver transplant were estimated to be 85%, 80%, 75%, 73%, and 71%, respectively. The results of the univariate meta-regression for defining the sources of heterogeneity for one-Year survival rate (SR) showed significant effects of bias (β _{high risk/ moderate} risk =0.059, 95% CI: 0.002, 0.115, P-Value=0.04) and follow up time (β=-0.0002, 95% CI: -0.0003, -0.00, P-Value=0.02) on heterogeneity.

Conclusion: The survival rate of liver transplant in Asia is comparable with the corresponding rate reported in the United States and Europe. This study provides a better view of the efficiency of medical cares, regarding liver transplantation. Medical care be enhanced to increase the survival of liver transplant patients.