Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain

Niloufar Mohamadian; Mehdi Seyedmoradi; Babak Izadi; Farhad Amirian; Mazaher Ramezani

doi:10.18502/bccr.v13i1.8833

Niloufar Mohamadian Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Mehdi Seyedmoradi Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Babak Izadi Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Farhad Amirian Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mazaher Ramezani Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

DOI: https://doi.org/10.18502/bccr.v13i1.8833

Keywords: Bone pain; Chronic Myeloid Leukemia; CML; Weight loss

Abstract

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. The incidence of CML increases slowly with age until the middle of the fourth decade, and then it rises rapidly. Anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man with bone pain and generalized abdominal pain. He also had weight loss because of anorexia and easy satiety. The qualitative probe-based real-time PCR (qRT-PCR) result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with Imatinib, the standard first-line treatment for CML, and showed clinical improvement. His pain also decreased, and he was discharged in good condition.