Fibrolamellar Hepatocellular Carcinoma: Report of a Rare Case with Rapid Progression and Unusual Metastatic Sites

Adeleh Rezagholizadeh Shirvan; Sarvazad Sotoudeh; Mamak Tahmasebi

doi:10.18502/bccr.v12i4.7980

Adeleh Rezagholizadeh Shirvan Palliative Medicine Unit, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
Sarvazad Sotoudeh Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Mamak Tahmasebi Department of Palliative Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/bccr.v12i4.7980

Keywords: Fibrolamellar Hepatocellular Carcinoma, HCC, Metastasis

Abstract

Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary liver cancer that occurs in young adults, and its biology is not well known. We present a 21-year-old woman with metastatic liver cancer 6 months after undergoing embolization procedures for a typical hemangioma. The pathological investigation confirmed metastatic FLHCC. Despite liver mass resection and lung metastasectomy, after 3 months, the tumor recurred. In 18F-FDG PET-CT scan, lung, ovary, colon, and peritoneal invasions were reported. Unfortunately, the patient died a year after diagnosis due to a rapid progression and multiple unusual metastatic sites.